Phase II study on the efficacy and safety of lapatinib administered beyond disease progression and combined with vinorelbine in HER-2/neu: Positive advanced breast cancer (CECOG LaVie Trial).

Christiane Thallinger, Istvan Lang, Cvetka Grasic Kuhar, Rupert Bartsch, Christian F. Singer, Lubos B. Petruzelka, Bohuslav Melichar, Regina Knittelfelder, Thomas Brodowicz and Christoph Zielinski

Journal of Clinical Oncology, 2015 ASCO Annual Meeting (May 29 – June 2, 2015).
Vol 33, No 15_suppl (May 20 Supplement), 2015: e11603 © 2015 American Society of Clinical Oncology

Bevacizumab plus paclitaxel versus bevacizumab plus capecitabine as first-line treatment for HER2-negative metastatic breast cancer: interim efficacy results of the randomised, open-label, non-inferiority, phase 3 TURANDOT trial

Istvan Lang, Thomas Brodowicz, Larisa Ryvo, Zsuzsanna Kahan, Richard Greil, Semir Beslija, Salomon M Stemmer, Bella Kaufman, Zanete Zvirbule, Günther G Steger, Bohuslav Melichar, Tadeusz Pienkowski, Daniela Sirbu, Diethelm Messinger, Christoph Zielinski

Lancet Oncol 2013; 14:125-33

The Lancet Oncology, Early Online Publication, 10 January 2013 doi:10.1016/S1470-2045(12)70566-1

Safety results from a phase III study (TURANDOT trial by CECOG) of first-line bevacizumab in combination with capecitabine or paclitaxel for HER-2-negative locally recurrent or metastatic breast cancer.

I.Lang, M.J. Inbar, Z. Kahan, R. Greil, S. Beslija, S. M. Stemmer, B. Kaufman, Z. Zvirbule, G. G. Steger, D. Messinger, T. Brodowicz, C. Zielinski

Eur J Cancer (2012)

Concomitant docetaxel plus gemcitabine versus sequential docetaxel followed by gemcitabine in anthracycline-pretreated metastatic or locally recurrent inoperable breast cancer patients: a prospective multicentre trial of the Central European Cooperative Oncology Group (CECOG).

A. Tomova, R. Bartsch, T. Brodowicz, V. Tzekova , C. Timcheva, C. Wiltschke, DA Gerges , J. Pawlega, S. Spanik, M. Inbar, CC Zielinski.

Breast Cancer Res. Treat Jan. 2010, 119(1) 169-76

Concomitant Docetaxel plus Gemcitabine (DG) vs. Sequential Docetaxel followed by Gemcitabine (D->) in Anthracycline-Pretreated Metastatic or Locally Recurrent Breast Cancer Patients: A Multicenter Phase III Trial of the Central European Cooperative Oncology Group (CECOG).

A. Tomova, T. Brodowicz, V. Tzekova, C. Timcheva, C. Wiltschke, D. Abi Gerges, J. Pawlega, S. Spanik, M. Inbar, C. Zielinski

J. Clin. Oncol (Supplement to 26) 2008: # 1106

Gemcitabine/Epirubicin/Paclitaxel versus 5-Fluorouracil/Epirubicin/Cyclophosphamide as First-Line Chemotherapy in Metastatic Breast Cancer: A Central European Cooperative Oncology Group International, Multicenter, Prospective, Randomized Phase III Trial.

C. Zielinski, S. Beslija, Z. Mrsic-Krmpotic, M. Welnicka-Jaskiewicz, C. Wiltschke, Z. Kahan, M. Grgic, V. Tzekova, M. Inbar, J. Cervek, I. Chernozemsky, J. Szanto, S. Spanik, M. Wagnerova, N. Ghilezan, J. Pawlega, D. Vrbanec, D. Khamtsov, V. Soldatenkova, T. Brodowicz.

JCO Mar 1, 2005:1401-1408; DOI:10.1200/JCO.2005.12.106.

Capecitabine vs. capecitabine + trastuzumab in patients with HER-2 positive metastatic breast cancer progressing during trastuzumab treatment – the TBP phase III study (GBG 26/BIG3-05).

von Minckwitz, C. Zielinski, E. Maarteense, P. Vogel, M. Schmidt, H. Eidtmann, T. Cufer, F. E. de Jongh, M. Kaufmann, S. Loibl

J. Clin. Oncol. 26:2008 (May 20 suppl; abstr. 1025).

Consensus on Medical Treatment of Metastatic Breast Cancer

Semir Beslija, Jacques Bonneterre, Harold J. Burstein, Michael Gnant, Pamela Goodwin, Volker Heinemann, Jacek Jassem, Wolfgang Köstler, Michael Krainer , Silvie Menard, David Miles, Lubos Petruzelka, Kurt Possinger, Peter Schmid, Edward Stadtmauer, Martin Stockler, Simon Van Belle, Charles Vogel, Nicholas, Wilcken, Christoph Wiltschke, Christoph Zielinski, Heinz Zwierzina

Breast Cancer Res. Treatment; 81 Suppl. 1, 1-7, 2003

Second Consensus on Medical Treatment of Metastatic Breast Cancer

Ann Oncol. 2007 Feb; 18(2): 215-25. Epub 2006 Jul 10. Review.

Third Consensus on Medical Treatment of Metastatic Breast Cancer

Ann Oncol. 2009 Nov; 20(11):1771-85. Epub 2009 Jul 16. Review.

Prof. Zielinski on Publications

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